Biotechnol Adv. 2026 Sep 7:109037. doi: 10.1016/j.biotechadv.2026.109037. Online ahead of print. ABSTRACT Terpenoids are among the most structurally diverse and commercially important natural products, with applications in pharmaceuticals, flavors, fragrances, and biofuels. Controllable supply of the universal precursors isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) remains a central limitation for microbial terpenoid production. The native…

Biotechnol Adv. 2026 Sep 7:109036. doi: 10.1016/j.biotechadv.2026.109036. Online ahead of print. ABSTRACT Natural fragrance compounds determine the sensory quality of food, cosmetics, and consumer goods. Driven by the limitations of traditional botanical extraction and petrochemical synthesis, sustainable biomanufacturing empowered by systems metabolic engineering and enzyme biocatalysis has emerged as a compelling alternative. This review systematically…

J Am Chem Soc. 2026 Sep 2;148(34):36842-36853. doi: 10.1021/jacs.6c08848. ABSTRACT Organophosphorus compounds constitute an important class of functional molecules with broad relevance in synthesis, catalysis, and medicinal chemistry. Despite their importance, biocatalytic C-P bond formation remains rare, with only a limited number of examples identified from natural product biosynthesis. Here we report a previously unexplored…

Int J Biol Macromol. 2026 Sep 4:154354. doi: 10.1016/j.ijbiomac.2026.154354. Online ahead of print. ABSTRACT A novel type III pullulan hydrolase (PulTS) was identified from the thermophilic bacterium Thermus scotoductus, representing the first bacterial member of this enzyme class. The recombinant PulTS exhibited optimal activity at pH 6.5 and 80 °C, with a specific activity of…

Nanoscale. 2026 Sep 4. doi: 10.1039/d6nr01065b. Online ahead of print. ABSTRACT Nano-metal-organic frameworks (nMOFs) represent a dynamic frontier in nanoscale coordination chemistry, offering exceptional control over composition, structure, and functionality. This review provides a material-chemistry-centric perspective on the evolution of nMOFs from coordination assemblies to practical biomedical materials. We aim to outline the conceptual foundations…

Org Lett. 2026 Sep 4;28(35):11013-11018. doi: 10.1021/acs.orglett.6c03023. ABSTRACT Chiral arylvinyl-substituted 3-hydroxy-5-oxo esters are valuable motifs in pharmaceuticals, yet their enantiocontrolled synthesis remains challenging. Herein, we report a biocatalytic system using ketoreductases (KREDs) for the highly C3-selective reduction of arylvinyl-substituted 3,5-dicarbonyl esters. Through semirational protein engineering, RasADH-E189D afforded the representative (S)-products in 89-99% conversion and 93-99%…

Int J Biol Macromol. 2026 Sep 4:154348. doi: 10.1016/j.ijbiomac.2026.154348. Online ahead of print. ABSTRACT Nitrile hydratase is a key enzyme for nitrile-to-amide hydration under mild conditions, yet its application is limited by low heterologous expression, poor solubility, and suboptimal catalysis. Here, we present an integrated strategy to enhance expression, assembly, and function of Pseudonocardia thermophila…

Zhongguo Zhong Yao Za Zhi. 2026 Aug;51(16):4623-4633. doi: 10.19540/j.cnki.cjcmm.20260330.401. ABSTRACT Coumarins mainly include simple coumarins, furanocoumarins, and pyranocoumarins. These compounds exhibit diverse biological activities, including anticoagulant, antibacterial, antitumor, and antioxidant effects, and thus possess high value for drug development. At present, coumarins are mainly obtained through traditional plant extraction methods. In recent years, synthetic biology…