BioCat Collective
Educating and Building a Broader Biocatalysis Community
Category: Biocatalysis
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J Oleo Sci. 2026;75(9):1069-1083. doi: 10.5650/jos.ess25285. ABSTRACT The industrial application of phenolic acids (PAs) is significantly limited by their low solubility and poor bioavailability in lipid-rich systems. Lipophilization via esterification of PAs with lipid matrices offers a promising approach to address these challenges. In this study, an efficient lipase-chemical catalytic method was developed for synthesizing…
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Eur J Med Chem. 2026 Aug 31;319:119275. doi: 10.1016/j.ejmech.2026.119275. Online ahead of print. ABSTRACT Animal-derived low-molecular-weight heparins (LMWHs) are essential anticoagulants but are associated with supply chain vulnerabilities and contamination risks, alongside incomplete protamine reversibility in clinical practice. Herein, we report the precision chemoenzymatic tailoring of bioengineered LMWHs from Escherichia coli K5 capsular polysaccharide (heparosan)…
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Methods Mol Biol. 2026;3032:47-67. doi: 10.1007/978-1-0716-5257-2_4. ABSTRACT Photobiocatalysis, an interdisciplinary frontier integrating chemistry, biology, and catalysis, drives enzymatic catalysis from natural reactions to new-to-nature transformations via protein engineering and photochemistry. This review centers on enzyme classes, covering nine key families: fatty acid photodecarboxylases (FAPs), nicotinamide-dependent reductases, flavin-dependent “ene”-reductases (EREDs), and others like artificial photoenzymes. We…
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Small. 2026 Sep 2:e75590. doi: 10.1002/smll.75590. Online ahead of print. ABSTRACT Oscillatory fluid flows underpin transport, mixing, and signal propagation in living systems, yet artificial microfluidic platforms rely almost extensively on external power or chemically driven gradients to reproduce such dynamics. Here, we introduce a fuel-free strategy based on photo-mechanical transduction, in which light is…
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Turk J Chem. 2026 Jun 9;50(4):386-400. doi: 10.55730/1300-0527.3904. eCollection 2026. ABSTRACT This study involved the immobilization of acetylcholinesterase (AChE) onto a natural thin membrane extracted from the inner epidermal layer of Allium cepa, with the aim of enhancing the enzyme’s stability, activity, and reusability for potential biotechnological applications. The membrane, composed of biocompatible polymers and…
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Nucleic Acids Res. 2026 Aug 24;54(16):gkag865. doi: 10.1093/nar/gkag865. ABSTRACT Prokaryotic Argonautes (pAgos) are widely distributed and provide immunity against invading DNA. Based on their domain architecture, pAgos are classified into three major groups: long-A, long-B, and short pAgos. Among them, long-B pAgos remain the least understood subgroup. Here, we show that a long-B pAgo-nuclease system…
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Front Microbiol. 2026 Aug 18;17:1891602. doi: 10.3389/fmicb.2026.1891602. eCollection 2026. ABSTRACT Natural products are a crucial source for drug discovery, but their traditional development is limited by resource availability, efficiency, chemical complexity, and the difficulty of rapidly diversifying biologically active scaffolds. This review addresses the central question of how biosynthetic precision and chemical diversification can be…
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RSC Adv. 2026 Sep 1. doi: 10.1039/d6ra05475g. Online ahead of print. ABSTRACT In the field of medicinal chemistry, the design of small molecules is acknowledged as an effective strategy. This study may contribute to the global fight against inflammatory diseases by focusing on the synthesis of novel α-aminophosphonate derivatives incorporating para-aminobenzoic acid (PABA) and benzocaine…
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Methods Mol Biol. 2026;3053:571-580. doi: 10.1007/978-1-0716-5376-0_34. ABSTRACT The assessment of blood group antigens is critical to transfusion medicine practice, as accurately identifying these antigens in both donors and patients is key to ensuring safe transfusions. Although plant lectins have long been used to aid in the identification of many carbohydrate-based blood group antigens, recent research…
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Methods Mol Biol. 2026;3032:47-67. doi: 10.1007/978-1-0716-5257-2_4. ABSTRACT Photobiocatalysis, an interdisciplinary frontier integrating chemistry, biology, and catalysis, drives enzymatic catalysis from natural reactions to new-to-nature transformations via protein engineering and photochemistry. This review centers on enzyme classes, covering nine key families: fatty acid photodecarboxylases (FAPs), nicotinamide-dependent reductases, flavin-dependent “ene”-reductases (EREDs), and others like artificial photoenzymes. We…