J Agric Food Chem. 2026 Sep 9;74(35):27808-27820. doi: 10.1021/acs.jafc.6c09645. ABSTRACT Zearalenone (ZEN) lactonases are promising biocatalysts for ZEN detoxification, yet the catalytic mechanism underlying ZEN hydrolysis remains poorly understood. Here, we combined structural analysis, quantum-mechanical (QM) calculations, and molecular dynamics (MD) simulations to elucidate the catalytic mechanism and guide enzyme engineering. QM and MD analyses…

J Agric Food Chem. 2026 Sep 9;74(35):27767-27778. doi: 10.1021/acs.jafc.6c08333. ABSTRACT d-Allulose is a promising low-calorie rare sweetener; however, its industrial production is limited by the insufficient catalytic activity and thermostability of d-allulose 3-epimerases (DAEases). In this study, a combinatorial engineering strategy integrating lid-domain modulation and computational design was developed to improve enzyme performance. Lid engineering…

J Hazard Mater. 2026 Sep 6;517:143531. doi: 10.1016/j.jhazmat.2026.143531. Online ahead of print. ABSTRACT Polyethylene terephthalate (PET) pollution necessitates biotechnological strategies that enhance interaction between the hydrophobic surfaces of PET and microbial biocatalysts. In this study, we developed PBW1-SAMF, an operationally defined autoclaved surface-active metabolite formulation derived from Trichoderma asperellum PBW1, which was isolated from plastic-contaminated…

J Agric Food Chem. 2026 Sep 9;74(35):27779-27794. doi: 10.1021/acs.jafc.6c09241. ABSTRACT The accumulation of acetaminophen (APAP) in agricultural soils and water systems poses risks to ecosystems and public health. This study characterizes Acinetobacter sp. DL27, an APAP-degrading strain with broad temperature and pH adaptability, demonstrating its bioremediation potential in soil and wastewater. Through high-resolution mass spectrometry,…

Biotechnol Lett. 2026 Sep 9;48(5):113. doi: 10.1007/s10529-026-03781-x. ABSTRACT This review examines Geobacillus sensu stricto as a source of thermostable glycoside hydrolases (GH) for biomass conversion, food processing, and enzyme engineering. Recent peer-reviewed literature was assessed with emphasis on taxonomy, genome-based Carbohydrate-Active Enzymes (CAZyme) prediction, biochemical validation, structural data, and engineering case studies. Taxonomic boundaries were…

Angew Chem Int Ed Engl. 2026 Sep 9:e2096522. doi: 10.1002/anie.2096522. Online ahead of print. ABSTRACT Pentacyclic triterpenoids (PTs) feature a steroid-like privileged scaffold, but late‑stage functionalization of their inert B‑ring C(sp3)─H bonds remains a formidable synthetic challenge due to the absence of directing groups and the consequent poor regio- and stereoselectivity. Here we report a…

Angew Chem Int Ed Engl. 2026 Sep 8:e9389619. doi: 10.1002/anie.9389619. Online ahead of print. ABSTRACT Typical biotic-abiotic hybrid systems utilize external energy (e.g., light or electricity) to boost biocatalytic reduction reactions. In this study, we propose a bifunctional core-shell architecture (graphitized carbon-coated nano iron, nFe0@CNT) to improve biocatalytic reduction performance without relying on external energy…

Chem Rec. 2026 Sep 8:e70219. doi: 10.1002/tcr.70219. Online ahead of print. ABSTRACT The benzopyran scaffold is a versatile family of heterocycles found in a wide range of bioactive natural products and functional molecules. In response to increasing environmental and regulatory demands, developing synthetic strategies focused on sustainability and low-impact conditions has become a central focus…

RSC Adv. 2026 Sep 8. doi: 10.1039/d6ra06848k. Online ahead of print. ABSTRACT The advent of antibiotic-resistant bacteria has escalated the exploration of novel antidiarrheal drugs. Persicaria vivipara is a perennial herb of the Polygonaceae family, located in high-elevation regions. The present study was designed to perform phytochemical analysis and investigate the in vivo and in…