Methods Mol Biol. 2026;3069:89-102. doi: 10.1007/978-1-0716-5508-5_6. ABSTRACT Activity-based ubiquitin probes serve as crucial tools for capturing and elucidating the molecular mechanisms of E3 ligase-catalyzed substrate ubiquitination. We recently reported a chemoenzymatic strategy for generating ubiquitin chain extension probes, which offers advantages such as mild reaction conditions, simple operation, and high specificity, thereby providing new opportunities…

Isr J Chem. 2026 Sep;66(5):e70036. doi: 10.1002/ijch.70036. Epub 2026 Aug 5. ABSTRACT In the cell wall of Gram-positive bacteria, wall teichoic acid (WTA) is an abundant and conserved virulence factor. WTAs are especially relevant to methicillin-resistant Staphylococcus aureus. Tremendous synthetic efforts have permitted investigations of the terminal end of this glycopolymer. However, the peptidoglycan (PG)…

Appl Biochem Biotechnol. 2026 Aug 5. doi: 10.1007/s12010-026-05856-x. Online ahead of print. ABSTRACT With the global population growth and the accelerating industrialization process, the demand for chemical intermediates and basic chemicals has been continuously rising. Against this backdrop, the conversion of renewable lignocellulosic biomass into high-value platform molecules has emerged as a strategic direction for…

Carbohydr Res. 2026 Jul 31;568:110057. doi: 10.1016/j.carres.2026.110057. Online ahead of print. ABSTRACT Sulfosugars are organosulfur metabolites that contribute to global sulfur cycling, yet the metabolism of the rarer sulfofucose (SFuc) remains poorly defined, in part due to limited access to authentic standards. We report a scalable five-step synthesis of SFuc from d-galactose, including a uniformly…

STAR Protoc. 2026 Aug 4;7(3):104762. doi: 10.1016/j.xpro.2026.104762. Online ahead of print. ABSTRACT Backbone thiazole moieties (Thz) are prevalent structural features in peptidic natural products and contribute to favorable physicochemical properties. Here, we describe a protocol for in vitro chemoenzymatic synthesis of artificial Thz-containing macrocyclic peptides compatible with mRNA display workflows. We provide steps for preparing…

Methods Mol Biol. 2026;3018:289-311. doi: 10.1007/978-1-0716-5166-7_19. ABSTRACT Glycosylation is an important post-translational modification that can alter the biological activities of antibodies. In monoclonal antibody biotherapeutic products, glycosylation of the Fc-domain, which is often sensitive to manufacturing conditions, can alter product potency by affecting its interactions with host immune cells. Improving control of antibody glycosylation to…

Science. 2026 Jul 30;393(6810):aef5438. doi: 10.1126/science.aef5438. Epub 2026 Jul 30. ABSTRACT Lignans constitute a diverse family of plant metabolites with therapeutic potential. Among them, podophyllotoxin-type aryltetralin lignans serve as precursors for etoposide and teniposide. Etoposide is an essential anticancer medicine approved for first-line treatment of small cell lung cancer, whereas teniposide is used for treatment…

Chem. 2024 Nov 14;10(11):3488-3502. doi: 10.1016/j.chempr.2024.08.003. NO ABSTRACT PMID:42524445 | PMC:PMC13411156 | DOI:10.1016/j.chempr.2024.08.003

Angew Chem Int Ed Engl. 2026 Jul 27:e7795967. doi: 10.1002/anie.7795967. Online ahead of print. ABSTRACT The dynamic glycan layer that surrounds human and microbial cells plays an essential role in the immune system’s capacity to maintain immune tolerance and equilibrium, fight pathogens and cancer. Endogenous anti-glycan antibodies are an indispensable part of immune surveillance, identifying…

Curr Opin Chem Biol. 2026 Jul 24;94:102735. doi: 10.1016/j.cbpa.2026.102735. Online ahead of print. ABSTRACT Protein N- and O-glycosylation are among the most common and essential post-translational modifications and are implicated in numerous physiological and pathological processes. The efficient assembly of structurally defined N- and O-glycans remains a major challenge due to their structural complexity and…