Biotechnol Bioeng. 2026 Sep 6. doi: 10.1002/bit.70373. Online ahead of print. ABSTRACT 28-epi-homobrassinolide (28-epi-HBL), a bioactive analog of the steroidal phytohormone brassinolide, exhibits broad biological activities and considerable application potential. However, conventional chemical routes remain limited by tetrahydroxylation step that relies on highly toxic osmium tetroxide in combination with costly chiral ligands, whereas the Baeyer-Villiger…

ChemMedChem. 2026 Sep 14;21(17):e70487. doi: 10.1002/cmdc.70487. ABSTRACT The glycopeptide antibiotics (GPAs) remain clinical antibiotics used against drug-resistant Gram-positive infections. The discovery of GPAs continues, with new type IIa and V GPAs, the kineomicins, the rimomycins, and corbomycin, being recently identified. Despite this larger repertoire of GPA scaffolds and crosslinking types, limitations remain with the in…

J Oleo Sci. 2026;75(9):1069-1083. doi: 10.5650/jos.ess25285. ABSTRACT The industrial application of phenolic acids (PAs) is significantly limited by their low solubility and poor bioavailability in lipid-rich systems. Lipophilization via esterification of PAs with lipid matrices offers a promising approach to address these challenges. In this study, an efficient lipase-chemical catalytic method was developed for synthesizing…

Curr Opin Chem Biol. 2026 Sep 2;94:102753. doi: 10.1016/j.cbpa.2026.102753. Online ahead of print. ABSTRACT Proteoglycans (PGs) are intricate macromolecules decorated with linear polysulfated glycosaminoglycans (GAGs) that play critical roles in orchestrating a wide range of physiological and pathological events. Advances in the utilization of recombinant enzymes and biosynthetic pathways have expedited the production of defined…

Eur J Med Chem. 2026 Aug 31;319:119275. doi: 10.1016/j.ejmech.2026.119275. Online ahead of print. ABSTRACT Animal-derived low-molecular-weight heparins (LMWHs) are essential anticoagulants but are associated with supply chain vulnerabilities and contamination risks, alongside incomplete protamine reversibility in clinical practice. Herein, we report the precision chemoenzymatic tailoring of bioengineered LMWHs from Escherichia coli K5 capsular polysaccharide (heparosan)…

Methods Mol Biol. 2026;3053:571-580. doi: 10.1007/978-1-0716-5376-0_34. ABSTRACT The assessment of blood group antigens is critical to transfusion medicine practice, as accurately identifying these antigens in both donors and patients is key to ensuring safe transfusions. Although plant lectins have long been used to aid in the identification of many carbohydrate-based blood group antigens, recent research…

J Sci Food Agric. 2026 Aug 20. doi: 10.1002/jsfa.71008. Online ahead of print. ABSTRACT BACKGROUND: Phytosterols, particularly β-sitosterol, exhibit well-recognized cholesterol-lowering activity; however, their practical application is constrained by rigid molecular structures and limited structural tunability. Rational molecular modification combined with the introduction of flexible linkers may provide an effective approach to improve their physicochemical…

Org Biomol Chem. 2026 Aug 17. doi: 10.1039/d6ob01079b. Online ahead of print. ABSTRACT Synthetic efforts directed towards the asymmetric total synthesis of two naturally occurring fungal macrolactams, melearorides A and B, were disclosed in this article. The strategy involves a late-stage intramolecular macrolactonisation approach for constructing a 13-membered macrolactam framework. For both molecules, the crucial…

Carbohydr Res. 2026 Aug 6;569:110060. doi: 10.1016/j.carres.2026.110060. Online ahead of print. ABSTRACT This review characterizes the mechanisms of action of animal polysaccharides (chitin, chitosan, hyaluronan, chondroitin sulfate, dermatan sulfate, keratan sulfate, heparin/heparan sulfate) based on their structural and conformational features. A systematic search was conducted in PubMed, Scopus, Web of Science, and the Russian Citation…

Bioorg Chem. 2026 Aug 10;181:110358. doi: 10.1016/j.bioorg.2026.110358. Online ahead of print. ABSTRACT Heparanase (HPSE) is a promising therapeutic target, yet current heparin-derived inhibitors are limited by structural heterogeneity, poor selectivity, and off-target anticoagulant effects. Here, we synthesized a library of structurally defined heparan sulfate (HS) oligosaccharides via a robust chemoenzymatic strategy, enabling a systematic investigation…