Chem Sci. 2026 Aug 5. doi: 10.1039/d6sc01721e. Online ahead of print. ABSTRACT Natural product biosynthetic cytochrome P450s (CYPs) are of increasing interest for their incredible ability to selectively activate inert C-H bonds on highly complex substrates. However, these enzymes are understudied due to difficulties accessing substrates. Here, we use our recently developed peptide cyclisation chemistry…

Discov Nano. 2026 Aug 3;21(1):372. doi: 10.1186/s11671-026-04800-6. ABSTRACT A green synthetic approach was developed for the preparation of a NiCoO₂ nanocomposite using an aqueous extract of Moringa oleifera as both a reducing and stabilizing agent. The synthesized NiCoO₂ nanocomposite exhibited high crystallinity and measurable antimicrobial activity. Detailed characterization using XRD, UV-visible spectroscopy, fluorescence spectroscopy, FTIR,…

Nat Prod Rep. 2026 Jul 31. doi: 10.1039/d6np00046k. Online ahead of print. ABSTRACT Covering: up to 2025Protoberberine alkaloids (PBs) and tetrahydroprotoberberine alkaloids (THPBs) exhibit diverse pharmacological activities, driving significant interest in their efficient synthesis. This review systematically categorizes recent advances in the total synthesis of these alkaloids based on core-ring-closure strategies. For protoberberines, key methodologies…

Mater Horiz. 2026 Jul 30. doi: 10.1039/d6mh00874g. Online ahead of print. ABSTRACT Stimulus-responsive hydrogels have emerged as versatile platforms for soft robotics and environmental remediation, yet most systems remain limited to either mechanical actuation or catalytic function, with few achieving synergistic coupling where motion actively optimizes chemical performance. Moreover, existing platforms often require elaborate fabrication…

Research (Wash D C). 2026 Jul 28;9:1368. doi: 10.34133/research.1368. eCollection 2026. ABSTRACT Nanozymes are emerging as versatile antimicrobial agents to tackle drug-resistant infections and biofilm-associated persistence. In this review, we present an integrated framework that links natural enzyme-mediated host defense to the rational development of antimicrobial nanozymes, and summarize recent advances through a mechanism-materials-engineering-application pipeline.…

Acc Chem Res. 2026 Jul 21. doi: 10.1021/acs.accounts.6c00368. Online ahead of print. ABSTRACT ConspectusModern organic synthesis aims to prepare the target molecule in a minimal number of steps. Hence, the efficiency, selectivity, and predictability of each of these steps need to be carefully optimized, even at a late stage of a synthetic route. This is…

Langmuir. 2026 Jul 21. doi: 10.1021/acs.langmuir.6c01158. Online ahead of print. ABSTRACT The self-assembly behavior of chiral surfactants has attracted much attention because of their crucial role in functional materials such as asymmetric catalysis and chiral separation. In this study, molecular dynamics simulations were performed to systematically investigate the effect of different chiral configurations of the…

Nano Lett. 2026 Jul 15. doi: 10.1021/acs.nanolett.6c02822. Online ahead of print. ABSTRACT The hydrogen evolution reaction (HER) is central to clean hydrogen production, yet its application in alkaline water electrolysis is severely limited by intrinsically sluggish kinetics and the poor long-term stability of Pt-based catalysts, particularly at industrially relevant current densities. Here, we propose a…

Angew Chem Int Ed Engl. 2026 Jul 15:e8342567. doi: 10.1002/anie.8342567. Online ahead of print. ABSTRACT Bioinspired nanochannel systems provide attractive platforms for coupling molecular recognition with ion transport regulation; however, integrating selective binding with efficient signal amplification remains challenging. In this study, we report a multi-level light-responsive asymmetric mesoporous nanochannel constructed via sequential interfacial assembly.…

Angew Chem Int Ed Engl. 2026 Jul 15:e1032601. doi: 10.1002/anie.1032601. Online ahead of print. ABSTRACT The precise synthesis of perovskite single crystals with tailored exposed facets is crucial for enhancing the performance of optoelectronic materials. However, the controlled preparation of perovskite single-crystal with different exposed facets is challenging, because perovskite tends to grow thermodynamically stable…