BioCat Collective

Adv Mater. 2026 Jul 9:e74020. doi: 10.1002/adma.74020. Online ahead of print. ABSTRACT Osteomyelitis, primarily caused by methicillin-resistant Staphylococcus aureus (MRSA), poses critical clinical challenges, including drug-resistant infections and insufficient bone regeneration. Herein, we propose a mechano-electro-chemical energy conversion paradigm based on an atomic-to-nanoscale synergistic strategy, realized by constructing a heterojunction… Read more: Atomic-to-Nanoscale Engineering of Piezocatalytic Heterojunctions for Ultrasound-Triggered Osteomyelitis Therapy

ArXiv [Preprint]. 2026 Jul 1:arXiv:2607.01362v1. ABSTRACT Quantum mechanical (QM) cluster models provide an effective framework for mechanistic studies of enzymatic reactions but remain computationally demanding. Neural network potentials (NNPs) offer a promising route to reduce this cost, but enzymes present challenges beyond small molecules, including large system sizes, implicit-solvent environments,… Read more: Enerzyme: A Framework for Efficient Training of Reactive Neural Network Potentials for Enzyme Catalysis with Application to Methyltransferases

bioRxiv [Preprint]. 2026 Jul 1:2025.03.19.642801. doi: 10.1101/2025.03.19.642801. ABSTRACT Many proteins’ biological functions rely on interconversions between multiple conformations occurring at micro-to millisecond (µs-ms) timescales. A lack of standardized, large-scale experimental data has hindered obtaining a more predictive understanding of these motions. After curating >100 Nuclear Magnetic Resonance (NMR) relaxation datasets,… Read more: Learning millisecond protein dynamics from what is missing in NMR spectra

J Colloid Interface Sci. 2026 Jul 5;724(Pt 1):141071. doi: 10.1016/j.jcis.2026.141071. Online ahead of print. ABSTRACT Gas sensing plays a critical role across diverse fields, including medical diagnostics, industrial safety, and environmental monitoring. However, conventional gas sensors often suffer from poor selectivity and limited sensitivity, especially at low concentrations. Herein, we… Read more: Light-regulated reconfigurable MXene-hydrogel gas sensing system via machine learning

Mol Plant. 2026 Jul 8:S1674-2052(26)00223-6. doi: 10.1016/j.molp.2026.07.004. Online ahead of print. ABSTRACT Diterpenoid alkaloids (DAs) are pharmaceutically important metabolites and mainly occur in the Ranunculaceae. Despite their structural complexity, all DAs originate from C20 diterpenoid scaffolds, making the elucidation of C20-DA biosynthesis pivotal for understanding and engineering this entire alkaloid… Read more: A Minimal Four-Enzyme Suite Enables Biosynthesis of the C20 Diterpenoid Alkaloid Atisinium

Biotechnol Biofuels Bioprod. 2026 Jul 8. doi: 10.1186/s13068-026-02793-z. Online ahead of print. ABSTRACT BACKGROUND: The discovery of novel biocatalysts for the sustainable valorization of complex biomass feedstocks remains a significant challenge. Domain-centric exploration of characterized CAZyme families offers a promising but underexplored strategy for identifying enzymes with unusual architectures and… Read more: Discovery of a multifunctional chitinase-cellulase from Thermococcus chitonophagus with expanded polysaccharide specificity

Enzyme Microb Technol. 2026 Jul 7;200:110932. doi: 10.1016/j.enzmictec.2026.110932. Online ahead of print. ABSTRACT The application of steam-exploded green coconut fiber (GCF) (an agro-industrial waste) was studied as a support for the immobilization of lipases, using lipase B from Candida antarctica (CALB), lipase from Pseudomonas fluorescens (PFL) or the engineered lipase… Read more: Evaluation of steam-exploded green coconut fiber as support for the immobilization of lipases fromPseudomonas fluorescens,Candida antarcticaB, and Eversa

Nature. 2026 Jul 8. doi: 10.1038/s41586-026-10744-9. Online ahead of print. ABSTRACT Methanogens are central to global carbon cycling and among the largest biological sources of methane, a potent greenhouse gas1. At the heart of their energy metabolism lies the Hdr-Vhu-Fwd super-assembly, which couples H2 oxidation with CO2 reduction through flavin-based… Read more: Architecture of the 8 MDa Hdr-Vhu-Fwd super-assembly in class I methanogens

Plant Cell Physiol. 2026 Jul 8:pcag095. doi: 10.1093/pcp/pcag095. Online ahead of print. ABSTRACT The plant extracellular space, including the cell wall, is a dynamic signaling compartment outside the plasma membrane that plays crucial roles in cell-cell communication and developmental coordination. Although early embryogenesis is known to be orchestrated by both… Read more: The extracellular regulatory network and key factors governing early embryogenesis in Nicotiana tabacum

Nat Prod Rep. 2026 Jul 8. doi: 10.1039/d6np00049e. Online ahead of print. ABSTRACT Coverage of selected chemoenzymatic natural product syntheses reported in the period 2021-2025Chemoenzymatic synthesis has emerged as a powerful strategy for the efficient construction and diversification of complex natural products by integrating the selectivity of biocatalysis with the… Read more: Recent advances in the strategic use of multiple enzymatic transformations in the total synthesis of natural products

Nat Commun. 2026 Jul 7. doi: 10.1038/s41467-026-75314-z. Online ahead of print. ABSTRACT Enzyme immobilization is pivotal to sustainable biocatalysis, yet the most widespread protocol of physical adsorption on static porous supports suffers from enzyme leakage and short catalytic lifespan. We introduce a dynamic-pore mechano-locking strategy employing tetrafluoroazobenzene-engineered covalent organic frameworks… Read more: Mechanically locking enzymes in covalent organic frameworks via light-responsive nanohands for stable biocatalysis

Int J Biol Macromol. 2026 Jul 7:153396. doi: 10.1016/j.ijbiomac.2026.153396. Online ahead of print. ABSTRACT The anthocyanin biosynthetic pathway (ABP), a branch of the phenylpropanoid pathway, is responsible for the production of a wide range of flavonoid compounds in plants. Anthocyanin-related glutathione transferases (arGSTs) have long been proposed to act as… Read more: Structural and biochemical insights into an anthocyanin-related glutathione transferase from bilberry and its inhibition by quercetin

Chembiochem. 2026 Jul 14;27(13):e70459. doi: 10.1002/cbic.70459. ABSTRACT The aminohexanoate oligomer hydrolase enzymes, NylCs, have emerged as lead biocatalysts for their potential to depolymerize nylon in a bioremediation context. Protein engineering efforts have thus far improved thermostability and activity, but conversion of the polymer to smaller oligomers remains low. With the… Read more: Trylons: Polyamide Surrogate Substrates Enable High-Throughput Screening of Nylon-Degrading Enzymes

Angew Chem Int Ed Engl. 2026 Jul 7:e1402106. doi: 10.1002/anie.1402106. Online ahead of print. ABSTRACT gem-Difluorophosphonates are pivotal structural motifs in pharmaceuticals and bioactive molecules. While photoenzymatic catalysis provides a powerful platform to overcome the challenges of enantioselective synthesis, engineering enzymes for non-natural transformations remains an arduous, labor-intensive process. Although… Read more: Machine-Learning-Enabled Rapid Evolution of Photoenzymes for the Asymmetric Synthesis of gem-Difluorophosphonates

J Agric Food Chem. 2026 Jul 7. doi: 10.1021/acs.jafc.5c17439. Online ahead of print. ABSTRACT (R)-N-(2,6-dimethylphenyl) aminopropionic acid methyl ester ((R)-DMPM) is a key chiral intermediate for the fungicide N-(2,6-Dimethylphenyl)-N-(methoxyacetyl)-alanine methyl ester ((R)-Metalaxyl). The biological function of the (R)-Metalaxyl is heavily dependent on its R-configuration, however, conventional chemical or single-esterase esterification… Read more: Highly Stereoselective Synthesis of the Chiral Fungicide’s Intermediate (<em>R</em>)-<em>N</em>-(2,6-Dimethylphenyl) Aminopropionic Acid Methyl Ester via an Esterase-Lipase Cascade

Commun Chem. 2026 Jul 9;9(1):240. doi: 10.1038/s42004-026-02128-x. ABSTRACT α-Tertiary amino acids (ATAAs), featuring a fully substituted α-carbon bearing two carbon substituents, are valuable building blocks in natural products, pharmaceuticals, and agrochemicals, yet their stereoselective synthesis remains a longstanding challenge in conventional chemical synthesis. Recent advances in enzymatic catalysis have provided… Read more: Emerging enzymatic strategies for the synthesis of α-tertiary amino acids

J Am Chem Soc. 2026 Jul 8. doi: 10.1021/jacs.6c07143. Online ahead of print. ABSTRACT Fatty acid photodecarboxylase (FAP) is a photoenzyme that converts fatty acids into hydrocarbons through light-driven radical chemistry. Although the early photochemical steps have been elucidated, the molecular mechanism governing the catalytic termination remains unresolved. Here, we… Read more: Molecular Mechanism of the Catalytic Radical Termination in Fatty Acid Photodecarboxylase

J Am Chem Soc. 2026 Jul 8. doi: 10.1021/jacs.6c07143. Online ahead of print. ABSTRACT Fatty acid photodecarboxylase (FAP) is a photoenzyme that converts fatty acids into hydrocarbons through light-driven radical chemistry. Although the early photochemical steps have been elucidated, the molecular mechanism governing the catalytic termination remains unresolved. Here, we… Read more: Molecular Mechanism of the Catalytic Radical Termination in Fatty Acid Photodecarboxylase

J Am Chem Soc. 2026 Jul 8. doi: 10.1021/jacs.6c07143. Online ahead of print. ABSTRACT Fatty acid photodecarboxylase (FAP) is a photoenzyme that converts fatty acids into hydrocarbons through light-driven radical chemistry. Although the early photochemical steps have been elucidated, the molecular mechanism governing the catalytic termination remains unresolved. Here, we… Read more: Molecular Mechanism of the Catalytic Radical Termination in Fatty Acid Photodecarboxylase

J Am Chem Soc. 2026 Jul 8. doi: 10.1021/jacs.6c07143. Online ahead of print. ABSTRACT Fatty acid photodecarboxylase (FAP) is a photoenzyme that converts fatty acids into hydrocarbons through light-driven radical chemistry. Although the early photochemical steps have been elucidated, the molecular mechanism governing the catalytic termination remains unresolved. Here, we… Read more: Molecular Mechanism of the Catalytic Radical Termination in Fatty Acid Photodecarboxylase

N Biotechnol. 2026 Jul 2:S1871-6784(26)00085-3. doi: 10.1016/j.nbt.2026.06.010. Online ahead of print. ABSTRACT A major challenge in developing effective photocatalysts lies in engineering the efficient coupling of one-electron photochemistry with the multi-electron requirements of chemical transformations. Here we demonstrate biohybrid assemblies that achieve this key performance requirement by storing photoenergized electrons… Read more: Engineering Cytochromes for Photocatalysis: Biohybrid Assemblies for Light-Driven Dye Decoloration

Front Chem. 2026 Jun 16;14:1878757. doi: 10.3389/fchem.2026.1878757. eCollection 2026. ABSTRACT Conventional nanozymes still suffer from limited catalytic efficiency and poor substrate selectivity, which impede their clinical translation. Recently, photo-responsive nanozymes have emerged as a promising platform for precision biomedicine by integrating photocatalytic processes with enzyme-mimetic catalysis, enabling spatiotemporally controlled enhancement… Read more: Photo-responsive nanozymes: from photocatalytic mechanisms to precision therapy

Colloids Surf B Biointerfaces. 2026 Jun 21;267:115923. doi: 10.1016/j.colsurfb.2026.115923. Online ahead of print. ABSTRACT Burn wounds infected with Staphylococcus aureus (S. aureus) are often characterized by excessive early inflammation, which leads to persistent oxidative stress, pain, and delayed healing. To overcome the limitations of conventional photosensitizers, which may induce reactive… Read more: Solar-simulated light-driven ROS-responsive CuxO-TiO(2-X) microneedle patch for intelligent antibacterial and regenerative therapy of infected burn wounds

Adv Sci (Weinh). 2026 Jun 22:e76240. doi: 10.1002/advs.76240. Online ahead of print. ABSTRACT The dynamic interplay between bacteria and host cancer cells plays a critical role in tumor microenvironment modulation, bacterial pathogenesis, and potential oncotherapy applications. However, traditional methods often fail to capture transient or spatially restricted molecular interactions at… Read more: Use of the “Ru-1O2-Hydrazide” System Catalyzed by Metallic Ruthenium Complexes to Decipher the Interaction Between Microbes and Host Cancer Cells

Chem Rec. 2026 Jun 21:e70197. doi: 10.1002/tcr.70197. Online ahead of print. ABSTRACT The importance of catalysis in the development of waste management systems in the circular economy is undeniable. This review emphasizes the emerging potential of nature-based bio-inspired catalysis to advance waste valorization. It discusses the potential of bio-inspired catalysis… Read more: Bio-Inspired Catalytic Pathways in Green Chemistry: Recent Innovations in Waste Valorization Processes-A Review

J Am Chem Soc. 2026 Jun 19. doi: 10.1021/jacs.6c03130. Online ahead of print. ABSTRACT Light-induced dehalogenation by flavoenzymes offers a promising route to generate acyl radicals in photoenzymatic catalysis, but current applications are largely limited to α-acyl halides. Mechanistic studies are needed to understand this substituent position effect to engineer… Read more: Dynamics and Mechanism of Photoenzymatic Dehalogenation Reactions through Electron-Transfer Bifurcation

Langmuir. 2026 Jun 16. doi: 10.1021/acs.langmuir.6c00112. Online ahead of print. ABSTRACT The excessive discharge of wastewater containing methylene blue (MB) has caused certain adverse effects on human health and daily life. This highlights the urgent need for the development of safe and environmentally friendly methods of degradation. In this study,… Read more: Development of Peroxymonosulfate Catalytic System and Photoenzymatic Catalytic System Utilizing Zn-Doped g-C(3)N(4) for the Degradation of Methylene Blue in Water

Org Biomol Chem. 2026 Jun 1. doi: 10.1039/d6ob00560h. Online ahead of print. ABSTRACT Recent advances have demonstrated that certain enzymes utilizing photoactive cofactors can be redirected upon light excitation to catalyze reactions entirely unrelated to their evolved functions. Given that charge-transfer interactions between substrates and cofactors can be facilitated by… Read more: Photoenzymatic new-to-nature transformations via electron donor-acceptor complexes

J Mater Chem B. 2026 Jun 12. doi: 10.1039/d6tb00152a. Online ahead of print. ABSTRACT Triplet-triplet annihilation upconversion (TTA-UC) liposomes are of emerging interest because of their potential bioapplications in biosensing/imaging and light-driven therapeutic delivery. However, a potential challenge in vivo is their stability, since liposomes are prone to enzymatic degradation.… Read more: Impact of phospholipase A2 hydrolysis on triplet-triplet annihilation upconversion liposomes

Chem Rec. 2026 Jun 15:e70195. doi: 10.1002/tcr.70195. Online ahead of print. ABSTRACT Ionic liquids (ILs) have attracted extensive attention in the field of photocatalytic CO2 reduction due to their unique advantages in the synthesis of photocatalytic materials and the regulation of interfacial reactions. However, the key regulatory mechanisms of photogenerated… Read more: Multistep Regulation of Ionic Liquids in Photocatalytic CO2 Reduction: From Capture, Preactivation, Carrier to Pathway Control

Front Microbiol. 2026 Jun 16;17:1866040. doi: 10.3389/fmicb.2026.1866040. eCollection 2026. ABSTRACT The DRT3 bacterial defense system reveals a previously undocumented mode of specificity in DNA synthesis, wherein a protein active site, rather than a complementary nucleic acid strand, dictates nucleotide incorporation. This mechanism necessitates a precise spatial configuration. DRT3 does not… Read more: Protein-directed nucleotide selection in the DRT3 defense system: mechanism, biological context, and constraints on programmability

FEBS Lett. 2026 Jun 25. doi: 10.1002/1873-3468.70400. Online ahead of print. ABSTRACT It is important to understand how the fascinating diversity of modern enzymes has manifested itself since the onset of life. A powerful approach to address this question is the computational and experimental retracing of evolutionary processes by protein… Read more: Reconstructing enzyme evolution by protein engineering

Biophys Rev. 2026 Feb 17;18(2):307-325. doi: 10.1007/s12551-026-01418-x. eCollection 2026 Apr. ABSTRACT Protein nanopores have evolved into a powerful biophysical tool, from direct DNA sequencing to versatile molecular sensors that detect RNA, proteins, aptamers, and low-molecular-weight analytes. This review summarizes the current state of nanopore technologies for biopolymer sequencing and metabolite… Read more: Biophysics of nanopore technologies: a roadmap for engineering protein channels as universal molecular sensors

Transl Oncol. 2026 Jun 6;70:102851. doi: 10.1016/j.tranon.2026.102851. Online ahead of print. ABSTRACT Nanozymes represent a transformative convergence of chemistry, nanotechnology, and biomedicine, giving rise to a new generation of enzyme-mimicking nanomaterials. Unlike natural enzymes that function optimally within narrow physiological ranges, nanozymes exhibit exceptional structural adaptability, tunable catalytic activity, and… Read more: Engineering nanozymes for cancer theranostics: Chemical design, catalytic intelligence, and translational oncology frontiers

Int J Biol Macromol. 2026 May 20:152585. doi: 10.1016/j.ijbiomac.2026.152585. Online ahead of print. ABSTRACT Lignocellulosic biomass (LCB), a second-generation feedstock for cellulosic ethanol production, requires efficient pretreatment. This step is critical in biorefinery processes. During enzymatic hydrolysis, lignin limits cellulase accessibility, whereas β-glucosidase (BGL) functions as a rate-limiting enzyme. This… Read more: Mechanisms and strategies for lignin-targeted pretreatment and beta-glucosidase molecular engineering in enhancing cellulase hydrolysis efficiency: A review

FEBS J. 2026 May 15. doi: 10.1111/febs.70584. Online ahead of print. ABSTRACT A key step in the evolution of lignin-degrading enzymes is revealed by the observation that, unlike other heme proteins studied to date, ClassII peroxidases exhibit minimal energy transfer from tryptophan to heme residues. Bioinformatics analyses and molecular dynamics… Read more: Molecular dynamics simulations and fluorescence spectroscopy suggest reduced tryptophan-to-heme energy transfer facilitates lignin degradation in ClassII peroxidases

Foods. 2026 Apr 30;15(9):1555. doi: 10.3390/foods15091555. ABSTRACT This review comprehensively examines the structural architecture, catalytic mechanisms, and targeted molecular engineering of α-amylase (primarily the GH13 family), a pivotal biocatalyst in the food industry. We highlight diverse microbial sources of α-amylases and their cost-effective heterologous expression in well-characterized hosts like Bacillus… Read more: α-Amylase: Its Structure, Molecular Modification, and Application in the Food Field

World J Microbiol Biotechnol. 2026 May 9;42(6):273. doi: 10.1007/s11274-026-05005-w. ABSTRACT Lytic polysaccharide monooxygenases (LPMOs) are a class of copper-dependent oxidases capable of cleaving glycosidic bonds in crystalline polysaccharides through oxidative mechanisms, playing a pivotal role in biomass refining and green biomanufacturing. However, natural LPMOs still face technical bottlenecks such as… Read more: Protein engineering and high-throughput screening of lytic polysaccharide monooxygenases: strategies, challenges, and prospects for industrial applications

Nat Commun. 2026 May 2. doi: 10.1038/s41467-026-72534-1. Online ahead of print. ABSTRACT Enzymes can exist in multiple stable functional states or sub-states, revealing substantial molecule-to-molecule heterogeneity in catalytic rates even within populations expressed from a clonal gene. Increasing evidence suggests that biological systems have evolved to exploit these functional sub-states… Read more: Single-molecule kinetic exploration of functional sub-states in an evolving phosphotriesterase

ACS Catal. 2026 Mar 30;16(8):7669-7682. doi: 10.1021/acscatal.6c00759. eCollection 2026 Apr 17. ABSTRACT Large language models (LLMs) have demonstrated their limitations in addressing the design of active proteins that rely on intricate intramolecular interactions, particularly in the engineering of biocatalysts. Conducting real-world studies from targeted laboratory assays has become the de… Read more: Generative Artificial Intelligence-Empowered Virtual Evolution of Enzyme with the VERnet Model

Biotechnol Adv. 2026 Apr 8:108895. doi: 10.1016/j.biotechadv.2026.108895. Online ahead of print. ABSTRACT Evolutionary engineering is a key strategy for obtaining industrial strains with high stress tolerance and productivity, as well as improving enzyme performance. However, low natural mutation rates, small in vitro mutation libraries, and lengthy phenotypic screening cycles constrain… Read more: Advances in in vivo continuous evolution technologies for strain development and enzyme engineering

Front Microbiol. 2026 Feb 27;17:1754802. doi: 10.3389/fmicb.2026.1754802. eCollection 2026. ABSTRACT Extremophiles are microorganisms that thrive in environments previously thought to be uninhabitable, including extreme temperature, salinity, pH, pressure, and radiation. These organisms, found in Archaea, Bacteria, and Eukarya, exhibit distinct structural, metabolic, and genetic adaptations, such as enhanced enzyme stability,… Read more: Molecular adaptations and engineering of extremophiles for synthetic biology and biotechnological applications

Plant Biotechnol J. 2026 Mar 14. doi: 10.1111/pbi.70612. Online ahead of print. ABSTRACT Belamcanda chinensis is a non-leguminous medicinal plant rich in bioactive isoflavones; however, the lack of a high-quality reference genome has limited elucidation of its isoflavone biosynthetic and modification network. Here, we present the first near telomere-to-telomere genome… Read more: A Near Telomere-to-Telomere Genome of Belamcanda chinensis Provides Insights Into Genome Evolution and the Biosynthesis of Characteristic Isoflavones

Plant Biotechnol J. 2026 Feb 19. doi: 10.1111/pbi.70592. Online ahead of print. ABSTRACT Iridoids constitute a prominent class of plant-specialised metabolites, with carbocyclic iridoids (e.g., geniposide) and secoiridoids (e.g., loganin) diverging early in their biosynthetic pathways. This divergence is marked by substrate-specific carboxyl methyltransferases-GjGAMT and CrLAMT-that catalyse the decisive methylation… Read more: The Structure of Carboxyl Methyltransferase Provides Insights Into the Substrate Specificity and Divergent Evolution of Iridoid

Nat Commun. 2026 Feb 19;17(1):2945. doi: 10.1038/s41467-026-69706-4. ABSTRACT C-prenylated flavonoids possess notable pharmaceutical potential, but their production is hindered by the challenging selective prenylation of their unstable polyphenolic cores. Natural prenyltransferases offer a direct route but suffer from low activity and incomplete mechanistic understanding. Here, we report a directed evolution… Read more: Tuning aromatic cage occupancy in prenyltransferases enables selective and efficient production of rare c-prenylated flavonoids

J Am Chem Soc. 2026 Jul 10. doi: 10.1021/jacs.6c12362. Online ahead of print. NO ABSTRACT PMID:42429779 | DOI:10.1021/jacs.6c12362

Sci Rep. 2026 Jul 9;16(1):21432. doi: 10.1038/s41598-026-60865-4. ABSTRACT Control over copper nuclearity is a key issue in bioinspired oxidation chemistry, yet its mechanistic consequences in sulfur-donor environments remain insufficiently understood. Here, remote tert-butyl substitution on a flexible dithioether-dithiolate ligand scaffold switches the preferred copper(II) assembly from binuclear [CuS4]2 to mononuclear… Read more: Steric control of copper nuclearity in sulfur ligated oxidase mimics alters catechol and phenoxazinone oxidation

Chemistry. 2026 Jul 8:e71406. doi: 10.1002/chem.71406. Online ahead of print. ABSTRACT Intracellular liquid-liquid phase separation underpins the formation of biomolecular condensates that spatially organize and regulate biochemical reactions. Synthetic coacervates have emerged as promising analogues for constructing biomimetic microreactors; however, their practical utility is often limited by poor stability under… Read more: pH-Tolerant Tripeptide Coacervates as Biomimetic Catalytic Microreactors

Dalton Trans. 2026 Jul 6. doi: 10.1039/d6dt00632a. Online ahead of print. ABSTRACT Two mononuclear Cu(II) complexes, [Cu(L1)]+ (1+) and [Cu(L2)(H2O)]+ (2+), were synthesized as molecular electrocatalysts for the oxygen reduction reaction (ORR). Ligand L1– provides an N5-donor framework, whereas L2– furnishes an N4-coordination environment; both incorporate a redox-active N-carboxyamidoquinolate unit… Read more: Copper(II) complexes for electrocatalytic dioxygen reduction: controlling selectivity <em>via</em> a proton relay mode

Natl Sci Rev. 2026 Apr 2;13(12):nwag207. doi: 10.1093/nsr/nwag207. eCollection 2026 Jun. ABSTRACT Selective chemical upcycling of waste polyethylene (PE) into high-value aromatics is conceptually very attractive. Yet, up to now the aromatic product selectivity typically remains below 50%, mainly limited by competing hydrogenolysis. We report here a cascade process that… Read more: Oxygen-mediated tandem polyethylene upcycling for selective aromatic synthesis

Inorg Chem. 2026 Jun 27. doi: 10.1021/acs.inorgchem.6c01380. Online ahead of print. ABSTRACT The valorization of CO2 waste into useful materials is a key endeavor in the field of sustainable chemistry. Molecular catalysts that convert CO2 to CO through electrochemical reduction are difficult to optimize because of scaling relations known as… Read more: Escaping the Iron Law of Electrochemical CO2 Reduction Using Pd12L24 Cages as Artificial 2nd Coordination Spheres

Molecules. 2026 Jun 11;31(12):2047. doi: 10.3390/molecules31122047. ABSTRACT CO2 hydrogenation to methanol is achieved by homogeneous catalysts through a formic acid derivative. Previous studies have focused on using large amounts of additives to activate this intermediate, such as strong acids, amines and alcohols. Hydrogenation of CO2 under basic conditions has been… Read more: Cooperative Dinuclear Activation of a Formate Intermediate in the Hydrogenation of CO2 to Methanol

Nat Commun. 2026 Jun 25. doi: 10.1038/s41467-026-73463-9. Online ahead of print. ABSTRACT Photosensitive topochemical polymerization, characterized by lattice-controlled reaction sites and rates, enables the production of highly crystalline and isotactic polymers, providing a powerful synthesis route for advancing high-performance lithographic technologies. However, the substantial challenge of achieving precise molecular packing… Read more: High-performance topochemical polymerization-based photo-carving with sub-50 nm resolution utilizing visible light

Sci Adv. 2026 Jun 26;12(26):eaee9634. doi: 10.1126/sciadv.aee9634. Epub 2026 Jun 24. ABSTRACT Photoelectrochemical nitrogen (N) fixation to ammonia (NH3) is a sustainable route for hydrogen storage yet limited by the stubborn N≡N bond and competitive interfacial reaction kinetics. Inspired by nitrogenase, we design single-atom iron (Fe)-doped tungsten oxide (WO3) subnanowires… Read more: A subnanoscale dynamic-integrated catalytic system for bioinspired photoelectrochemical ammonia synthesis

Angew Chem Int Ed Engl. 2026 Jun 24:e8733637. doi: 10.1002/anie.8733637. Online ahead of print. ABSTRACT Stimuli-responsive supramolecular polymerization with high precision is essential for developing adaptive materials with programmable kinetics and functions. Here, we present a redox-responsive strategy that integrates chemical redox reactions and electrochemical potential to direct the self-assembly… Read more: Electrochemically Triggered Supramolecular Polymerization Under Kinetic Control

ACS Sens. 2026 Jun 23. doi: 10.1021/acssensors.5c03873. Online ahead of print. ABSTRACT The extensive use of glyphosate (Glyp) in agriculture has led to persistent residues in food and the environment, which pose potential threats to ecosystems and human health. Thus, rapid, sensitive, and selective on-site detection strategies are urgently needed.… Read more: Bioinspired Zr-Cu Dual Sites Regulate Hydrogen Peroxide Heterolysis for Naked-Eye Glyphosate Sensing

Small. 2026 Jun 21:e74126. doi: 10.1002/smll.74126. Online ahead of print. ABSTRACT The application of proton exchange membrane water electrolysis (PEMWE) technology heavily relies on breakthroughs in oxygen evolution reaction (OER) catalyst performance. Traditional iridium-based catalysts suffer from bottlenecks such as low atomic utilization and insufficient long-term operational stability, limiting their… Read more: Highly Interdiffused W-Ir Interfaces Enhances Acidic Oxygen Evolution

Nanoscale. 2026 Jun 15. doi: 10.1039/d6nr02052f. Online ahead of print. ABSTRACT Porous organic polymers (POPs) constructed via Schiff-base chemistry has garnered increasing attention as advanced materials for heterogeneous catalysis, owing to their inherent structural tunability, high surface area, and chemical stability. Herein, we report the rational design and synthesis of… Read more: Using nature’s blueprint porous organic polymeric nanotraps enables the interfacial activation of the hosted amine and CO2

Bioact Mater. 2026 Jun 6;65:347-364. doi: 10.1016/j.bioactmat.2026.05.061. eCollection 2026 Nov. ABSTRACT Immobilized enzymes offer a sustainable, cost-effective alternative to soluble catalysis, but an adaptable platform preserving native conformation, stability, and broad enzyme/material compatibility remains elusive. We report a facile, general, jigsaw-designed platform via co-assembling silk fibroin (SF), protocatechualdehyde (PA), and… Read more: Bioinspired silk-catechol-enzyme co-assemblies as jigsaw-designed conformation-locking bioactive-biocatalytic platforms

Colloids Surf B Biointerfaces. 2026 Jun 5;266:115886. doi: 10.1016/j.colsurfb.2026.115886. Online ahead of print. ABSTRACT Conventional nanoparticle-labeled lateral flow assays often face limitations such as aggregation in incompatible buffers, complex preparation procedures, and high costs. Here, we present a nanolabel-free lateral flow chromatographic platform that integrates lossless strand displacement amplification of… Read more: Bioinspired DNA sponge interface coupled with deoxyribozyme autography for nanoparticle-free nucleic acid detection on a strip

Front Mol Biosci. 2026 Jun 25;13:1846568. doi: 10.3389/fmolb.2026.1846568. eCollection 2026. ABSTRACT Mucins are densely O-glycosylated proteins that establish mucosal barriers, mediate immune recognition, and serve as ligands for host lectins and microbes. However, mucin O-glycan structure-function relationships remain poorly defined due to inherent glycoform heterogeneity. Glycoengineering has emerged as a… Read more: Glycoengineering strategies for constructing defined Mucin O-glycans

Curr Opin Chem Biol. 2026 Jul 8;93:102722. doi: 10.1016/j.cbpa.2026.102722. Online ahead of print. ABSTRACT Cytochrome P450 enzymes are versatile oxidative enzymes that perform a wide range of oxidation reactions. Here, we summarise recent results showing the widespread role of P450s in the cyclisation of peptides. These enzymes have great potential… Read more: Peptide crosslinking by cytochrome P450 enzymes: Diversity, discovery and developments

Carbohydr Res. 2026 Jun 26;567:110019. doi: 10.1016/j.carres.2026.110019. Online ahead of print. ABSTRACT Antibody Fc glycosylation critically influences effector functions, motivating the development of chemoenzymatic strategies to generate homogeneous glycoforms. However, limited availability and high cost of mammalian glycosyltransferases remain to be significant constraints. Here, we report the high-yield expression of… Read more: Chemoenzymatic synthesis of unusual antibody glycoforms using E. coli expressed human and bovine beta-1,4-galactosyltransferase and their mutants

Org Lett. 2026 Jun 29. doi: 10.1021/acs.orglett.6c02562. Online ahead of print. NO ABSTRACT PMID:42374778 | DOI:10.1021/acs.orglett.6c02562

ChemSusChem. 2026 Jul 14;19(13):e70835. doi: 10.1002/cssc.70835. ABSTRACT The development of sustainable biorefineries requires integrated fractionation strategies capable of preserving carbohydrate streams while generating high-value lignin and bioactive fractions. In this study, olive pomace was valorized through a cascade approach combining optimized microwave-assisted extraction (MAE) of phenolic compounds, natural deep eutectic… Read more: Tunable Natural Deep Eutectic Solvents-Driven Fractionation of Olive Pomace in an Integrated Biorefinery: Linking Lignin Structural Tailoring to Carbohydrate Valorization and Biopolymer Production

JACS Au. 2026 Jun 10;6(6):3376-3385. doi: 10.1021/jacsau.6c00382. eCollection 2026 Jun 22. ABSTRACT 16α-Methyl glucocorticoids are a renowned family of steroid molecules with diverse important pharmaceutical applications, and development of innovative, practical, and divergent synthetic routes toward these steroids is highly desirable. Herein, we report a unified stereocontrolled synthesis of five… Read more: Unified Chemoenzymatic Approach to 16alpha-Methyl Glucocorticoids: Stereocontrolled Synthesis of (+)-Dexamethasone, (+)-Mometasone, (+)-Flumethasone, (+)-Halometasone, and (+)-Vamorolone

Methods Enzymol. 2026;731:223-252. doi: 10.1016/bs.mie.2026.05.007. Epub 2026 Jun 1. ABSTRACT The ability of native and engineered nucleic acid-processing enzymes to incorporate clickable nucleotide substrates has greatly advanced bioorthogonal labeling of nucleic acids, overcoming the limitations of conventional solid-phase oligonucleotide (ON) synthesis. In this chemoenzymatic approach, template-dependent polymerases routinely enable the… Read more: Chemoenzymatic labeling of RNA using terminal uridylyl transferase and bioorthogonal click chemistry

Methods Enzymol. 2026;731:485-501. doi: 10.1016/bs.mie.2026.05.002. Epub 2026 May 25. ABSTRACT Site-specific labeling of antibodies is highly valuable for diagnostic and therapeutic applications. The chemoenzymatic Fc glycan remodeling method provides a platform for site-specific antibody functionalization without perturbing antigen recognition. In this chapter, we describe a one-pot enzymatic method to produce… Read more: Site-specific antibody labeling via endo-S2 mediated Fc glycan remodeling

J Org Chem. 2026 Jun 25. doi: 10.1021/acs.joc.6c00980. Online ahead of print. ABSTRACT A chemo-enzymatic approach to enantiopure (S)-linezolid 1 is presented. The key chiral intermediate, (R)-alcohol 4, was obtained via CRL lipase-catalyzed kinetic resolution of (RS)-4, affording an enantiopure (R)-alcohol 4 with 98.5% ees (enantiomeric excess of substrate) and… Read more: Biocatalytic Method for the Synthesis of the Key Linezolid Intermediate and Its Subsequent Conversion to Linezolid

Nat Commun. 2026 Jun 24. doi: 10.1038/s41467-026-74245-z. Online ahead of print. ABSTRACT Nature organizes enzymes in micro-compartments to enable efficient biosynthesis, inspiring multienzyme cascades for producing complex molecules. However, practical implementation is often limited by enzyme incompatibility, poor substrate transfer, and inefficient catalyst recycling. Here, we report a living biocatalytic… Read more: Assembly-Line Biosynthesis in Living-Cell Emulsions via Tunable Supramolecular Surface Chemistry