Org Lett. 2026 Jun 3. doi: 10.1021/acs.orglett.6c01748. Online ahead of print.

ABSTRACT

Herein, we report a redox-neutral photoredox-catalyzed anti-Markovnikov intermolecular hydroamidation of alkenes, achieved through the strategic integration of photoredox iron catalysis and thiol catalysis. Amidyl radicals are generated from readily accessible α-amido-oxy acids via photoredox iron-catalyzed decarboxylation under mild reaction conditions. This catalytic system displays an excellent substrate scope and broad functional group tolerance. The synthetic utility of this protocol is highlighted by its facile scalability and successful application in the late-stage functionalization of alkenes derived from biologically active molecules.

PMID:42231724 | DOI:10.1021/acs.orglett.6c01748