Methods Mol Biol. 2027;3064:207-221. doi: 10.1007/978-1-0716-5472-9_11.

ABSTRACT

In this chapter, we describe the application of lipases as catalysts in the synthesis of structurally different amides with pharmacological activities. Numerous products, many of them new compounds, were obtained in very good to excellent yield and a highly regioselective manner. The influence of various reaction parameters in the enzymatic reactions, such as enzyme source, nucleophile/substrate ratio, enzyme/substrate ratio, solvent, and temperature, was examined for each case.

PMID:42778856 | DOI:10.1007/978-1-0716-5472-9_11