Angew Chem Int Ed Engl. 2026 Aug 5:e26115. doi: 10.1002/anie.202526115. Online ahead of print.

ABSTRACT

As biocatalytic strategies for PET recycling reach maturation, insights gained from PET hydrolase research can be leveraged to inform the design of proteins and surface-functionalization strategies that promote stable association of functional proteins with PET surfaces, enabling the development of functional protein-plastic hybrid materials. Herein, we examine recent developments in biofunctionalization strategies of PET and related materials, with a focus on chemical biology approaches that offer more precise control of the orientation of proteins on PET and related materials. Biophysical insights from protein-polymer interface chemistry studies can inform protein selection, design, and engineering approaches to minimize denaturation and maximize function of proteins upon attachment to surfaces. Finally, we highlight applications of protein-functionalized PET and related synthetic polymers, including for biomedical applications and scalable biocatalysis, showcasing the potential of integrating biological activity into durable synthetic polymers.

PMID:42555549 | DOI:10.1002/anie.202526115