Org Lett. 2026 Apr 10. doi: 10.1021/acs.orglett.6c01268. Online ahead of print. ABSTRACT Isoindolinones are valuable nitrogen-containing heterocycles, yet efficient access to highly functionalized derivatives remains challenging. Herein, we report a bioinspired carbonyl alkylative amination enabled by Ca(II)/HFIP cooperative catalysis for the modular synthesis of 3-alkyl-N-substituted isoindolinones. This three-component cascade combines amines, ketoesters, and alkyl-1,4-dihydropyridines via…

Adv Mater. 2026 Apr 10:e23689. doi: 10.1002/adma.202523689. Online ahead of print. ABSTRACT Chirality is a fundamental property with profound implications in fields like pharmaceuticals, yet the separation of enantiomers remains a significant technical hurdle. This review chronicles the development of interfacial super-assembled hetero-structured chiral nanochannel membranes, a transformative approach for enantioseparation. We begin by systematically…

ACS Nano. 2026 Apr 8. doi: 10.1021/acsnano.6c00940. Online ahead of print. ABSTRACT The tandem strategy for electrochemical CO2 reduction (ECO2R), which utilizes CO gas as the essential intermediate, offers a promising route for converting CO2 into multicarbon (C2+) products. However, inefficient retention and utilization of the CO intermediate remain fundamental issues limiting the practical viability…

ChemSusChem. 2026 Apr 14;19(7):e202502322. doi: 10.1002/cssc.202502322. ABSTRACT The design and development of bioinspired coordination compounds are crucial for laying the foundation to deliver low-cost, energy-efficient materials that promote energy sustainability. In this work, isostructural copper complexes, Cu-LN2S2 and Cu-LN3S, in tune with the donor centers in the ligand backbone, (LN2S2 = 1,2-bis((pyridin-2-ylmethyl)thio)ethane and LN3S =N-(pyridin-2-ylmethyl)-2-((pyridine-2-ylmethyl)thio)ethane-1-amine)…

Anal Chem. 2026 Mar 30. doi: 10.1021/acs.analchem.6c00750. Online ahead of print. ABSTRACT Real-time and accurate monitoring of environmental pollutants is crucial for ecosystem protection and public health. Inspired by biological ion channels exhibiting ion selectivity, ion gating, and ion current rectification, solid-state nanochannels have emerged as promising label-free sensing platforms that can transduce recognition-induced interfacial…

Bioact Mater. 2026 Mar 18;62:447-462. doi: 10.1016/j.bioactmat.2026.02.053. eCollection 2026 Aug. ABSTRACT Catalysis is a fundamental principle of biological systems, yet synthetic biomaterials seldom incorporate catalytic activity as a core design principle. Here, we introduce a polymeric network constructed by crosslinking imidazole-functionalized polymers using Cu2+ ions, yielding an elastomer with enzyme-mimetic reactivity. This bioinspired design enables…

Acc Chem Res. 2026 Mar 28. doi: 10.1021/acs.accounts.6c00136. Online ahead of print. ABSTRACT ConspectusThe development of new methodologies for efficient and selective catalysis under mild, green conditions is critical in synthetic chemistry. While nanoconfined catalysis has emerged as a powerful way for modulating reaction pathways, existing systems lack continuously interconnected confined channels and fail to…

Biosens Bioelectron. 2026 Mar 24;304:118638. doi: 10.1016/j.bios.2026.118638. Online ahead of print. ABSTRACT Iron-sulfur clusters play central roles in electron transfer and redox catalysis in natural enzymes, yet their direct mimicry in nanozymes remains largely unexplored. Here, we report that reduced graphene oxide embedded with Fe2S6 clusters (Fe-S-rGO), which resembles iron-sulfur clusters present in natural ferredoxin,…

ACS Appl Mater Interfaces. 2026 Mar 27. doi: 10.1021/acsami.6c03253. Online ahead of print. ABSTRACT Laccases, a typical metalloenzyme, catalyze the oxidation of organic substrates while reducing molecular oxygen to water. Reconstructing the in-between states (IBS) of the laccase active site is essential for understanding its catalytic mechanism and for guiding artificial enzyme design. In this…

Chem Sci. 2026 Mar 19. doi: 10.1039/d5sc09412g. Online ahead of print. ABSTRACT The selective formation of metal-hydride intermediates represents a key mechanistic step in Mn-based CO2 reduction catalysis, yet remains kinetically challenging. Herein, we report the discovery of a secondary-sphere proton channel that markedly accelerates Mn-H formation in visible-light-driven CO2-to-formate conversion. Mn(i) bipyridyl complexes bearing…