BioCat Collective

January 2026

01-22-2026: 16-Step Scalable Chemoenzymatic Synthesis of Tetrodotoxin; Chen Peng, Weilin Wu, Yuxuan Ye*, Pengfei Hu* (https://pubs.acs.org/doi/10.1021/jacs.5c20700)

01-22-2026: Tuning Electron Transfer Pathway in [NiFe]-Hydrogenase via Silver Nanocluster-Directed Electron Injection; Wenjin Li, Yingying Zhao, Lei Wan, Yanxin Gao, Hang Luo, Jian Zhao, Tin Pou Lai,Liyun Zhang* (https://pubs.acs.org/doi/10.1021/acscatal.5c06176)

01-22-2026: A Library of Iron and a-Ketoglutarate Dependent Dioxygenases Enables the Synthesis of Six Fungal Natural Products; Gonzalo J Villegas Rodríguez, Evan O Romero, Jonathan C Perkins, Diego N Rojas,  Maximilian S Hrigora, Alison R H Narayan (https://chemrxiv.org/doi/full/10.26434/chemrxiv.10001506/v1) This is a preprint and has not been peer reviewed. Data may be preliminary.

01-21-2026: Total Synthesis of Allocyclinone A via Late-Stage Halogen Swapping; Tsung-Han Chao, Elizabeth B Barrois, Chad W Johnston, and Hans Renata (https://chemrxiv.org/doi/full/10.26434/chemrxiv.10001470/v1) This is a preprint and has not been peer reviewed. Data may be preliminary.

01-21-2026: Photoenzymatic Hydroalkylation Enables Streamlined Access to Aryl Glutarimide Precursors; Zhi Xu, Prasun Mukherjee, Steven Gossert, Stephen Thomas, Vasil H Vasilev, Eric R Welin, Yichen Tan, Shane M Mckenna, Megan A Emmanuel, Todd K Hyster (https://chemrxiv.org/doi/full/10.26434/chemrxiv.10001477/v1)This is a preprint and has not been peer reviewed. Data may be preliminary.

01-15-2026: Structure-guided engineering of membrane-binding regions for surfactant-free solubilization of direct electron transfer-type alcohol dehydrogenase; Konatsu Ichikawa, Taiki Adachi, Tomoko Miyata, Fumiaki Makino, Keiichi Namba, Yuki Kitazumi, Osamu Shirai, Keisei Sowa (https://chemrxiv.org/doi/full/10.26434/chemrxiv-2026-1xcj3)This is a preprint and has not been peer reviewed. Data may be preliminary.

01-15-2026: Engineered Flavin-Dependent Halogenases Catalyze C–C Bond Formation via Enantioselective Semipinacol Rearrangement; Xuzhong Shen, Paras Gupta, Pratibha Gandhi, IanGustavo Ramirez, Dibyendu Mondal, and Jared C. Lewis* (https://pubs.acs.org/doi/10.1021/jacs.5c20091)

01-15-2026: Alcohol Oxidase–Imine Reductase Cascade for One-Pot Chiral Amine Synthesis; Anya Miletic, Christopher J. Truby, Nicholas J. Turner, Rebecca E. Ruscoe*(https://pubs.acs.org/doi/10.1021/acscatal.5c06313)

01-14-202: Total Biosynthesis and Engineering of Cinatrins: Inhibitors of Phospholipase A2 and Squalene Synthase; Henrike Heinemann, Nick Gerlach, Eric Kuhnert, Jennifer Gerke, Bart Verwaaijen, Jörn Kalinowski, Marc Stadler, Russell Cox (https://chemrxiv.org/doi/full/10.26434/chemrxiv-2026-lv8gm) This is a preprint and has not been peer reviewed. Data may be preliminary.

01-13-2026: Establishing the Photoenzyme CvFAP as Platform for New-to-Nature Radical Biotransformations; Florian Weissensteinera, Cristina Bergab, Emilia Iglesias-Moncayoa, Sara Salehia, Isabel Oroz-Guineaa, Klaus Zanggera, Ferran Feixas, Marc Garcia-Borràs, Wolfgang Kroutila, Christoph K. Winklera* (https://chemrxiv.org/engage/chemrxiv/article-details/6945401eafb3b11118195770)

01-14-2026: Oxidative Rearrangement of Indoles Enabled by Promiscuous Cryptic Halogenation with Vanadium-Dependent Haloperoxidases; Hyung Ji Lee, Carter U. Brzezinski, Sergio A. Solis, Raina S. Semenick, Ana Villalobos Galindo, Sophia G. Barthel, John Bacsa, Kyle F. Biegasiewicz* (https://pubs.acs.org/doi/10.1021/acscatal.5c07839)

01-09-2026: Chemoenzymatic Triazolopyridine Synthesis Enabled by Cryptic Diazo Formation by Vanadium-Dependent Haloperoxidases; Manik Sharma and Kyle F. Biegasiewicz*(https://chemrxiv.org/engage/chemrxiv/article-details/695d9682900d745c43b68dd6) This content is a preprint and has not been peer-reviewed.

01-08-2026: Competition Between Enzymatic and Anodic Oxidation in Electro-chemical Galactose Oxidase Catalysis; Yawen Zhang, Scott E. Schaus* (https://chemrxiv.org/engage/chemrxiv/article-details/69598425900d745c430ff729) This content is a preprint and has not been peer-reviewed.

01-07-2026: Enzymatic Mannich Reaction for the Synthesis of γ-Chiral Amino-Substituted α-Amino Acids; Lu Wang, Duo Zhang, Kangni Yin, Guojing Wu, Xinyu Duan, Chunlei Yang, Lishuang Ma*, Xiaoyang Chen*, Jian Xu* (https://pubs.acs.org/doi/10.1021/acscatal.5c07217)

01-06-2026: Mechanistic Insights into Nitrogenase-Catalyzed Nitrogen Fixation: A QM/MM Study; Jiabin Yin, Jianqiang Feng, Zhenjia Gan, Bowen Li, Binju Wang*, Tong Zhu*, John Z. H. Zhang* (https://pubs.acs.org/doi/10.1021/acscatal.5c06838)

01-05-2026: Engineered Artificial Carboligase-Catalyzed Stereoselective Michael Addition of Nitroalkane to Cyclohexadienone; Li Zhang,Yushun Sun, Xiaofan Wu, Qi Wang, Zhigang Liu, Yunyun Yang*, Zedu Huang*, Fener Chen* (https://pubs.acs.org/doi/10.1021/acscatal.5c07465)

01-05-2026: Chemoenzymatic Diazo Synthesis Enabled by Enzymatic Halide Recycling with Vanadium-Dependent Haloperoxidases; Manik Sharma, Yue Li, Kirklin L. McWhorter, Tiffany V. Alvarez, Lorenzo Layug, Abbas Khambatti, Katherine M. Davis*, Kyle F. Biegasiewicz* (https://pubs.acs.org/doi/10.1021/jacs.5c17554)

01-03-2026: Synthesis and design of Nickel-Enzyme Ligand Framework for Catalytic Application; Carla Garcia-Sanz and Jose M. Palomo* (https://chemrxiv.org/engage/chemrxiv/article-details/69468ddde3cb457e13cd796b) This content is a preprint and has not been peer-reviewed.

01-01-2026: Computational Elucidation of the Mechanism by which a Pericyclase Controls Periselectivity in the Biosynthesis of Natural Product (−)-PF-1018; Ching Ching Lam, Qingyang Zhou, Xin Zang, Yi Tang, K. N. Houk* (https://pubs.acs.org/doi/10.1021/jacs.5c20844)

December 2025

12-30-2025: Structure and Mechanism of the Prenylated-FMN Maturase, PhdC; Daniel J. DiRocco, Ingrid Kilde, Dillon P. Langford, Pronay Roy, Shayandeep Bhaumik, Johnny Mendoza, Markos Koutmos, E. Neil G. Marsh* (https://pubs.acs.org/doi/10.1021/acscatal.5c08793)

12-30-2025: Asymmetric Reductive Amination of Structurally Diverse Ketones with an Engineered Amine Dehydrogenase; Lin Chen, Wencai Fan, Xinxin Liu, Yaxuan Fang, and Jin Zhu* ( https://chemrxiv.org/engage/chemrxiv/article-details/6945fc5e6e8e74030e8bd72b) This content is a preprint and has not been peer-reviewed.

12-30-2025: Visualization-Guided Rational Engineering of an Artificial Metallolyase for Highly Enantioselective Michael Addition; Saito Morikawa, Naoki Saegusa, Ryusei Matsumoto, Yoshitsugu Morita, and Nobutaka Fujieda* (https://chemrxiv.org/engage/chemrxiv/article-details/6947e246afb3b11118791f33) This content is a preprint and has not been peer-reviewed.

12-29-2025: Dynamics and Catalytic Conversion of the CO₂ Coproduct in Fatty Acid Photodecarboxylase; Adeline Bonvalet
Elsa Balduzzi, Bertrand Légeret, Laura Antonucci, Poutoum Samire, Xavier Solinas, Gilles Peltier, Frédéric Beisson, Pavel Müller, Manuel Joffre, Rainer Hienerwadel, Marten H. Vos, Catherine Berthomieu, Alexey Aleksandrov, Damien R. Sorigué* (https://pubs.acs.org/doi/10.1021/acscatal.5c08787)

12-29-2025: Dynamic Enantioconvergent Desaturation of 4,5-Disubstituted γ-Lactones in Whole Cells of Rhodococcus erythropolis; Maria C. Cancellieri, Filip Boratyński, Stefano Serra*, Dawid Hernik, Francesco G. Gatti* (https://pubs.acs.org/doi/10.1021/jacs.5c19136)

12-24-2025: Dual-Activity Mannosyltransferase Phosphorylases in Family 130 of Glycoside Hydrolases; Simon Ladeveze Laurence Tarquis, Gianluca Cioci, David Guieysse, Julien Durand, Régis Fauré, Ao Li, Jeremy Esque, Maxant Vivier, Yannick Malbert, Elisabeth Laville, Gabrielle Potocki-Veronese* (https://pubs.acs.org/doi/10.1021/acscatal.5c06782)

12-22-2025: Bifunctional P450 Catalyzes Sequential Hydroxylation and Macrocyclization in Emestrin A Biosynthesis; Jingwen Yu, Suitian Lai, Qin Li, Nanjin Ding, Nanyu Yao, Aimin Fu, Zhe Chen, Awei Che, Hucheng Zhu, Weiguang Sun, Junjun Liu*, Ying Ye*, Yonghui Zhang* (https://pubs.acs.org/doi/10.1021/acscatal.5c07040)

12-22-2025: Integrating Interfacial Ligand Tailoring and Machine Learning for Heterogeneous H₂-Driven Chemoenzymatic Synthesis; Luyao Ge, Heng Liang, Wei Lan, Maodi Wang*, Xiaoming Zhang, Aiping Jia, Xiang-Kui Gu*, Qihua Yang*, Xiaobo Li* (https://pubs.acs.org/doi/10.1021/acscatal.5c07427)

12-22-2025: Mechanistic Insight into Conformational Control of Enzyme Activity by Genetically Encoded Metal-Responsive Switches; Payal, Jonathan Thirman, Katherine A. Edmonds, Sandip Mishra, Nathan Blackwell, S. Zubi, Benoît Roux, Jared C. Lewis (https://chemrxiv.org/engage/chemrxiv/article-details/693c9ee508e316a05f2d28e9) This content is a preprint and has not been peer-reviewed.

12-22-2025: Electric fields enhance Diels–Alderase catalysis in Abyssomicin C biosynthesis; Rodrigo Recabarrena, Sam T. Johnsb, Adrian Bunzelc, Esteban Vöhringer-Martinez* and Marc W. van der Kamp (https://chemrxiv.org/engage/chemrxiv/article-details/693ffa4f08e316a05fdc4c87) This content is a preprint and has not been peer-reviewed.

12-22-2025:Characterisation and immobilisation study of the Haloperoxidase from Curvularia inaequalis: application to phenol derivatives; Lucas Bisel, Jana Vojčíková, Nicolo Villa, Rénato Froidevaux,and Egon Heusona* (https://chemrxiv.org/engage/chemrxiv/article-details/69413402afb3b1111863a2dc) This content is a preprint and has not been peer-reviewed.

12-22-2025: Chemoenzymatic Synthesis of Structurally Diverse Terpenoids from Farnesyl Pyrophosphates Modified at the Central Alkene Unit; Henry Struwe, Christopher Slotman, Laurent Höft, Gerald Dräger, Jörn Droste, Jörg Fohrer, Katharina Hausmann, Sascha Beutel, Dominik Kolling, Jesko Köhnke, and Andreas Kirschning* (https://pubs.acs.org/doi/10.1021/jacs.5c14636)

12-22-2025: Biosynthesis of 17-Carbon Terpenoids in Bacteria; Yao-Tao Duan, Chi Zhang, Aikaterini Koutsaviti, Mohamed A. Tammam, Maria Harizani, Vassilios Roussis, Yong Zhao*, Efstathia Ioannou*, Sotirios C. Kampranis* (https://pubs.acs.org/doi/10.1021/jacs.5c15311)

12-19-2025: Direct electrochemistry of enzymes that use and produce solar fuels: hydrogenase, formate dehydrogenase, CO-dehydrogenase and nitrogenase; Vincent Fourmond, Andrea di Giuliantonio, Miriam Malagnini, Laura Opdam, Nils Ostermann, Sophie Webb, Ross D. Milton* and Christophe L´eger∗ (https://chemrxiv.org/engage/chemrxiv/article-details/6942a195afb3b11118a88d71) This content is a preprint and has not been peer-reviewed.

12-19-2025: Biocatalytic Enantioselective Oxidation of N-Acyl-S-Methyl Sulfenamides for the Asymmetric Synthesis of S-Methyl Sulfoximines; Shivani Patel, James D. Finnigan, Jesmine Lim, Nathaniel S. Greenwood, Jonathan A. Ellman* (https://pubs.acs.org/doi/10.1021/acs.orglett.5c04701)

12-19-2025:Enzyme Engineering and Cofactor Recycling Enable Efficient Biosynthesis of Neuroactive 3α-OH-5β-H Steroids with C3 Glycosylation; Zhengwen Li, Bo Gu, Qiyue Wang, Mengting Liu, Shurong Ban*, Heng Song* (https://pubs.acs.org/doi/10.1021/acscatal.5c06187)

12-19-2025: Indigo Formation as a Predictor of Non-Native Aromatic Hydroxylation in Cytochrome P450 BM3; Jonathan N. Besna, Douglas J. Fansher, Donya Valikhani, Olivier Rousseau, Claudèle Lemay-St-Denis, Guillaume Lamoureux, Joelle N. Pelletier* (https://pubs.acs.org/doi/10.1021/acscatal.5c06523)

12-19-2025: Engineered ω-Transaminase Enables Remote Stereocontrol in the Synthesis of Chiral Pharmaceutical N-Heterocyclic Amines with Nonadjacent Stereocenters; Yuanzhen Zhang, Xiaozheng Wang, Xianqi Yin, Tingting Huang, Shuangjun Lin* (https://pubs.acs.org/doi/10.1021/acscatal.5c07044)

12-18-2025: Biocatalytic Production of a Key Chiral Intermediate of the HIV Capsid Inhibitor Lenacapavir; C. J. Taylor, G. J. Ford, A. E. Hutton, W. R. Birmingham, F. Zhao, Z. Xu, W. Finnigan,M. Ortmayer, C. W. Levy, M. S. Dunstan, R. Crawshaw, I. Rowles , A. P. Green* and N. J. Turner*(https://chemrxiv.org/engage/chemrxiv/article-details/693aaaecbc44e47cf4c4d575) This content is a preprint and has not been peer-reviewed.

12-12-2025: Directed Evolution of Artificial Aldolase for Enantioselective Biosynthesis of 3-Hydroxy-Oxindoles; Liangyu Feng,Jie Lei, Zhixi Zhu*,and Zhi Zhou* (https://pubs.acs.org/doi/10.1021/acs.orglett.5c04724)

12-07-2025: Structural and Mechanistic Basis for Orthoester Formation by αKG-Free Endoperoxide Isomerase in Novofumigatonin Biosynthesis; Yi Yang, Xuan Zhang, Takahiro Mori*, Zhiyang Quan, Takayoshi Awakawa, Yiling Ding, Binju Wang*, Ikuro Abe* (https://pubs.acs.org/doi/10.1021/jacs.5c14075)

12-04-2025: Metalloenzyme-Catalyzed Radical Reactions Unknown or Uncommon in Native Enzymology; Wenzhen Fu, Liu-Peng Zhao, and Yang Yang* (https://chemrxiv.org/engage/chemrxiv/article-details/692bdc2d65a54c2d4a5900e0) This content is a preprint and has not been peer-reviewed.

12-03-2025: Computational design of metallohydrolases; Donghyo Kim, Seth M. Woodbury, Woody Ahern, Doug Tischer, Alex Kang, Emily Joyce, Asim K. Bera, Nikita Hanikel, Saman Salike, Rohith Krishna, Jason Yim ,Samuel J. Pellock, Anna Lauko, Indrek Kalvet, Donald Hilvert & David Baker (https://doi.org/10.1038/s41586-025-09746-w)

12-02-2025: Refining the Substrate-Cofactor Disposition Model of Hyoscyamine 6β-Hydroxylase Catalysis Using Hyoscyamine Analogs; Richiro Ushimaru, Ridao Chen, Po-Hsun Fan, Xiao Liu, Mark W. Ruszczycky, Hung-wen Liu* (https://pubs.acs.org/doi/10.1021/jacs.5c17484)

12-01-2025: P450-Mediated Dual Cyclization Mechanisms for Pyrroloindoline Unit Formation in Bispyrrolidinoindoline Diketopiperazine Alkaloid Biosynthesis; Yeqing Du, Guangzheng Wei*, Tai-Ping Zhou, Yuhan Dai, Wenya Tian, Mancheng Tang, Zixin Deng, Binju Wang*, Xudong Qu (https://pubs.acs.org/doi/10.1021/jacs.5c14741)

November 2025

11-26-2025: Engineering a Formic Acid Reductase; Philipp Wichmann
Amelia Cox-Fermandois, Andreas M. Küffner, Uwe Linne, Tobias J. Erb, Maren Nattermann* (https://pubs.acs.org/doi/10.1021/acscatal.5c04079)

11-22-2025: Dihydroxy Terpene Synthase: Spatiotemporally Precise Manipulation of Water-Mediated Dihydroxylation via Stepwise Quenching of Carbocations; Zheng-Yu Huang, Kangwei Xu, Wen-Li Li, Chun-Xiu Li, Jiang Pan, Ruibo Wu*, Jian-He Xu* (https://pubs.acs.org/doi/10.1021/jacs.5c19381)

11-20-2025: Biocatalytic Synthesis of N-Protected α-Amino Acids through 1,3-Nitrogen Migration by Nonheme Iron Enzymes; Teng Yuan, Mengxi Zhang, Linqi Cheng, Xinzhe Zheng, Shiyu Jiang, Xiongyi Huang*, Han Xiao* (https://pubs.acs.org/doi/10.1021/jacs.5c11008)

11-20-2025: Biocatalytic- and Chemoproteomic-Guided Discovery of a PHGDH Inhibitor from Chemoenzymatic-Promoted DNA-Encoded Libraries Selection Platform; Yiwei Zhang, Yuqiu Lan, Rufeng Fan, Lei Feng, Guoliang Wang, Xinyuan Wu, Lulu Wen, Zhiqiang Duan, Yueyue Xia, Xudong Wang, Lingrui Zhang, Lu Zhou*, Minjia Tan*, Cangsong Liao*, Xiaojie Lu* (https://pubs.acs.org/doi/10.1021/jacs.5c14634)

11-19-2025: Methionine Salvage Enzyme Uses a Unique Mechanism to Overcome a Challenging Aldose–Ketose Isomerization; Subashi T. Ubayawardhana, Tamal Das, Stephanie A. Corio, Jennifer S. Hirschi*, Andrew S. Murkin* (https://pubs.acs.org/doi/10.1021/jacs.5c13980)

11-19-2025: Photoenzymatic C(sp³)–H Functionalization of 1,3-Dicarbonyls Enables Enantioselective Hydroalkylation of Styrenes; Ermeng Wang, Qiaoyu Zhang, Qinglong Shi*, Xiaoyu Wang, Ting Ma, Yixue Wu, Binju Wang*,Juntao Ye* (https://pubs.acs.org/doi/10.1021/jacs.5c17564)

11-18-2025: Experimental Evidence for Radical-Polar Crossover in Competition with, Rather Than Preceding, Alkene Formation by Microbial Ethylene-Forming Enzyme; Evan J. Burke, Chao Wang, Holly Lussier, Elvira R. Sayfutyarova, Alexey Silakov , Carsten Krebs*, J. Martin Bollinger Jr.*, Jeffrey W. Slater*(https://pubs.acs.org/doi/10.1021/jacs.5c13787)

11-10-2025: Bioinspired Fe Single-Atom Nanozyme Synergizes with Natural NarGH Dimer for High-Efficiency Photobiocatalytic Nitrate Conversion; Jiyong Bian, Jing Zhao, Zixuan Zhang, Dongfei Liu, Xianen Lan, Yang Liao, Xiaoqiang An*, Diannan Lu, Minmin Liang, Ruiping Liu, Junwang Tang*, Huijuan Liu, Jiuhui Qu (https://pubs.acs.org/doi/10.1021/jacs.5c07315)

October 2025

10-24-2025: Stereoselective Photoenzymatic Hydroarylation for the Construction of Quaternary Stereocenters; Felix C. Raps, Chufan A. Jin, Alexandra C. Brown, Damien Sorigué, Todd K. Hyster* (https://pubs.acs.org/doi/10.1021/jacs.5c12440)

10-20-2025: Direct Catalytic Deaminative Cyanation of Aliphatic Primary Amines; Jiang-Hao Xue, Shuang Lin, Jiawu Huang, Taeseok Kang, Bumsu Park, Mark Levin, Myojeong Kim, and Honggen Wang (https://chemrxiv.org/engage/chemrxiv/article-details/68f17790bc2ac3a0e0719d7c) This content is a preprint and has not been peer-reviewed. 

10-18-2025: Development of a Manufacturing Route toward AMG 193, an MTA-Cooperative PRMT5 Inhibitor; Athimoolam Arunachalampillai, Prashantha Chandrappa, Richard D. Crockett, Colin S. Gaines, Kelly Hu, Ted Judd, Venkata Chandrasekhar Kommuri, James I. Murray, John Nidhiry, Adrian Ortiz ,Jo Anna Robinson, Andreas R. Rötheli, Robert M. Vernon, Carolyn S. Wei, Shane Wells, Conner V. Wilson, Shuangning Xu, Kumiko Yamamoto*, and Lara E. Zetzsche* (https://pubs.acs.org/doi/10.1021/acs.oprd.5c00310)

10-16-2025: Biocatalytic Stereodivergent Construction of Axially Chiral Tri- and Tetrasubstituted Allenols via Desymmetric Hydroxylation;Xiao-Jian Zhou, Cheng-Cheng Song, An-Ni Wang, Mei-Xia Wang, Bei-Bei Liu, Lu Feng, and Yong-Zheng Chen* (https://pubs.acs.org/doi/10.1021/jacs.5c08146)

10-14-2025: An Expanded Molecular Model for the Activation of Methyl-Coenzyme M Reductase; Elliot B. Shelton, Shadi Yavari, Chau-wen Chou, Nana Shao, Shuning Wang, Evert C. Duin, William B. Whitman, Steven O. Mansoorabadi* (https://pubs.acs.org/doi/10.1021/acs.biochem.5c00494)

10-09-2025: Aminoacyl-tRNA Specificity of a Ligase Catalyzing Non-ribosomal Peptide Extension; Dinh T. Nguyen
Josseline S. Ramos-Figueroa, Alexander A. Vinogradov, Yuki Goto, Mayuresh G. Gadgil, Rebecca A. Splain, Hiroaki Suga, Wilfred A. van der Donk*, Douglas A. Mitchell*(https://pubs.acs.org/doi/10.1021/jacs.5c12610)

10-09-2025: Shaping the Glycan Landscape: Hidden Relationships between Linkage and Ring Distortions Induced by Carbohydrate-Active Enzymes; Isabell Louise Grothaus*, Paul Spellerberg, Carme Rovira, Lucio Colombi Ciacchi (https://pubs.acs.org/doi/10.1021/jacs.5c11504)

10-09-2025: Photobiocatalytic Radical Hydroalkylation with C(sp³)–H Bonds Enabled by Engineered Imine Reductase and Redox Buffering; Bin Chen, Ran Ge, Jinhai Yu, Ruiqi Zhu, Qin Zhu, Jiawei Zhang, Mingfeng Cao, Xiaoqiang Huang* (https://pubs.acs.org/doi/10.1021/jacs.5c10377)

10-08-2025: Directed Evolution of APOX for Proximity Labeling Using Phenols with High Redox Potentials; Sifei Fang, Leslie Acevedo, Alexander Solivais, Xu Zhou, Swapnali S. Patil,  Elliot S. Delfosse, Hang Yin, Brian L. Frey, Edwin R. Chapman, Lloyd M. Smith, Jeffrey D. Martell (https://chemrxiv.org/engage/chemrxiv/article-details/68e27cccbc2ac3a0e07d8536) This content is a preprint and has not been peer-reviewed.

10-07-2025: Mechanistic Interrogation of a PQQ and Rare Earth-Dependent Artificial Metalloenzyme; Mohd Taher, Peter J. Thompson, Carlos Nava-Matadamas, Austin T. Bruchs, Jennifer Bridwell-Rabb, Lisa Olshansky (https://pubs.acs.org/doi/10.1021/jacs.5c08540)

10-05-2025: Tryptophanase Mining and Characterization Towards the Biological Production of Indole Derivatives; Ruben M. de Boer, David Harding-Larsen, Stanislav Mazurenko, Ditte Hededam Welner (https://chemrxiv.org/engage/chemrxiv/article-details/68db9276f2aff1677032be9f) This content is a preprint and has not been peer-reviewed.

10-02-2025: Oxidative Rearrangement of Indoles Enabled by Promiscuous Cryptic Halogenation with Vanadium-Dependent Haloperoxidases; Hyung Ji Lee, Carter U. Brzezinski, Sergio A. Solis, Raina S. Semenick, Ana Villalobos Galindo, Sophia G. Barthel, John Bacsa, Kyle F. Biegasiewicz (https://chemrxiv.org/engage/chemrxiv/article-details/68dacf20f416303770df6ce7) This content is a preprint and has not been peer-reviewed.

10-01-2025: Reprogramming the Catalytic Pocket of Baeyer–Villiger Monooxygenase for Environmentally Compatible Synthesis of a Chiral Sulfoxide Pharmaceutical; Chen Zhao, Qiang Geng, Kun Shi, Jiang Pan, HuiLei Yu* (https://pubs.acs.org/doi/10.1021/acscatal.5c06238)

10-01-2025: Late-Stage C(sp³)–H Functionalization of Bioactive Piperazines; Masayuki Wasa, Soichiro Mori , Cunyuan Zhao, Yuankai Wang, Nathan Jackson (https://chemrxiv.org/engage/chemrxiv/article-details/68d694a6f2aff16770b2720d) This content is a preprint and has not been peer-reviewed.

10-01-2025: Connecting chemical and protein sequence space to predict biocatalytic reactions; Alexandra E. Paton, Daniil A. Boiko, Jonathan C. Perkins, Nicholas I. Cemalovic, Thiago Reschützegger, Gabe Gomes & Alison R. H. Narayan (https://doi.org/10.1038/s41586-025-09519-5)